ES17.02 Molecular Heterogeneity

Molecular Heterogeneity of Human

Interleukin 2 (IL-2,1 formerly termed T cell growth factor), discovered by Morgan et al. (1) is produced by T lymphocytes after antigen or mitogen stimulation and is required for the proliferation of activated T cells. IL-2 is an essential mediator o f the immune response (2, 3), and there is prel iminary evidence that it may also be responsible for the abnormal cell proliferation in h u m a n ...

Molecular heterogeneity of adherens junctions

We describe here the subcellular distributions of three junctional proteins in different adherens-type contacts. The proteins examined include vinculin, talin, and a recently described 135-kD protein (Volk, T., and B. Geiger, 1984, EMBO (Eur. Mol. Biol. Organ.) J., 10:2249-2260). Immunofluorescent localization of the three proteins indicated that while vinculin was ubiquitously present in all a...

Novel insights into the molecular heterogeneity of hepatocellular carcinoma Running head: HCC molecular heterogeneity

Inferring Molecular Processes Heterogeneity from Transcriptional Data

RNA microarrays and RNA-seq are nowadays standard technologies to study the transcriptional activity of cells. Most studies focus on tracking transcriptional changes caused by specific experimental conditions. Information referring to genes up- and downregulation is evaluated analyzing the behaviour of relatively large population of cells by averaging its properties. However, even assuming perf...

Clinical and Molecular Heterogeneity of RTEL1 Deficiency

Typical features of dyskeratosis congenita (DC) resulting from excessive telomere shortening include bone marrow failure (BMF), mucosal fragility, and pulmonary or liver fibrosis. In more severe cases, immune deficiency and recurring infections can add to disease severity. RTEL1 deficiency has recently been described as a major genetic etiology, but the molecular basis and clinical consequences...